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levoketoconazole will raise the amount or outcome of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.iloperidone boosts levels of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Iloperidone can be a time-dependent CYP3A inhibitor and could produce enhanced plasma level